1. Handorf AM, Chamberlain CS, Li WJ. Endogenously-produced Indian hedgehog regulates TGFB-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev 2015; 24:995-1007.
  2. Handorf AM, Zhou Y, Halanski MA, Li WJ. Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis 2015; 11:1-15.
  3. Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther 2015; 6:88.

    This paper is part of the ‘Emerging Investigators’ collection of Stem Cell Research & Therapy and was also recommend by F1000 Rheumatology & Clinical Immunology for reading.

  4. Jing X, Jin E, Mi HY, Li WJ, Peng XF, Turng LS. Hierarchically decorated electrospun poly(e-caprolactone)/nanohydroxyapatite composite nanofibers for bone tissue engineering. J Mater Sci 2015; 50:4174-4186.
  5. Chiu CY, Tsai TL, Vanderby R, Bradica G, Lou SL, Li WJ. Osteoblastogenesis of mesenchymal stem cells in 3-D culture enhanced by low-intensity pulsed ultrasound through soluble receptor activator of nuclear factor kappa B ligand. Ultrasound Med Bio 2015; 41:1842-1852.


  1. Saether EE, Chamberlain CS, Leiferman EM, Kondratko-Mittnacht JR, Li WJ, Brickson SL, Vanderby R. Enhanced medial collateral ligament healing using mesenchymal stem cells: dosage effects on cellular response and cytokine profile. Stem Cell Rev 2014; 10:86-96.
  2. Handorf AM, Li WJ. Induction of mesenchymal stem cell chondrogenesis through sequential administration of growth factors within specific temporal windows. J Cell Physio 2014; 229:162-171.
  3. Palumbo S, Tsai TL, Li WJ. Macrophage migration inhibitory factor regulate Akt signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells. Stem Cells Dev 2014; 23:852-865.

    This paper was recommend by F1000 Rheumatology & Clinical Immunology for reading.

  4. Tsai TL, Nelson BC, Anderson PA, Zdeblick TA, Li WJ. Intervertebral disc and tem cells co-cultured in biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor. Spine J 2014; 14:2127-2140.
  5. Czaplewski SK, Tsai TL, Duenwald-Kuehl SE, Vanderby R Jr, Li WJ. Tenogenic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells dictated by properties of braided nanofibrous scaffolds. Biomaterials 2014; 35:6907-6917.

    This paper was highlighted as special interest in the drug development sector and an advancement in medicine by Global Medical Discovery.

  6. Brown PT, Squire MW, Li WJ. Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Cell Tissue Res 2014; 358:149-164.
  7. Mi HY, Palumbo S, Jing X, Turng LS, Li WJ, Peng XF. Thermoplastic polyurethane/hydroxyapatite electrospun scaffolds for bone tissue engineering: effect of polymer properties and particle size. J Biomed Mater Res Part B 2014; 102:1434-1444.


  1. Tsai TL, Manner PA, Li WJ. Regulation of mesenchymal stem cell chondrogenesis by glucose through protein kinase C/Transforming growth factor signaling. Osteoarthritis Cartilage 2013; 21:368-376.
  2. Barber JG, Handorf AM, Allee TJ, Li WJ. Braided nanofibrous scaffold for tendon and ligament tissue engineering. Tissue Eng Part A 2013; 19:1265-1274.
  3. Brown PT, Handorf AM, Jeon WB, Li WJ. Stem cell-based tissue engineering approaches for musculoskeletal regeneration. Curr Pharm Des 2013; 19: 3429-3445.
  4. Palumbo SL, Li WJ. Osteoprotegerin enhances osteogenesis of human mesenchymal stem cells. Tissue Eng Part A 2013; 319:1942-1955.
  5. Pflum ZE, Palumbo SL, Li WJ. Adverse effect of demineralized bone powder on osteogenesis of human mesenchymal stem cells. Exp Cell Res 2013; 319:1942-1955.
    This paper was selected as a highlighted article in the section of Stem Cells by World Biomedical Frontiers in November 2013.


  1. Cui ZX, Nelson B, Peng YY, Li K, Pilla S, Li WJ, Turng LS, Shen CY. Fabrication and characterization of injection molded poly(epsilon-caprolactone) and poly(epsilon-caprolactone)/hydroxyaptite scaffolds for tissue engineering. Mater Sci Eng C Mater Biol Appl 2012; 32:1674-1681.
  2. Koepsel JT, Brown PT, Loveland SG, Li WJ, Murphy WL. Combinatorial screening of chemically defined human mesenchymal stem cell culture substrates. J Mater Chem 2012; 22:19474-19481.


  1. Handrof AM, Li WJ. Fibroblast growth factor-2 primes human mesenchymal stem cells for enhanced chondrogenesis. PLoS One 2011; 6:e22887.
  2. Giri J, Li WJ, Tuan RS, Cicerone MD. Stabilization of proteins by nanoencapsulation in sugar-glass for tissue engineering and drug delivery applications. Adv Mater 2011; 23:4861-4867.


  1. Barber JG, Li WJ. Nanostructured scaffolds for biology and tissue engineering. Nano Life 2010; 1&2:109-120.


  1. Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng Part B Rev 2009; 15:171-193.
  2. Baker BM, Handorf AM, Ionescu LC, Li WJ, Mauck RL. New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev Med Devices 2009; 6:515-532.