• Weishar R, Lee MS, Fontana G, Hematti P, Li WJ. Endothelin-1 reduces catabolic activity of human mesenchymal stem/stromal cells during chondro- and osteo-lineage differentiation. Biochem Biophys Res Commun 2020; 529:180-185.


  • Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV. Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties. Sci Adv 2019; 5:eaau7375.
  • Lee MS, Wang J, Yuan H, Jiao H, Tsai TL, Squire MW, Li WJ. Endothelin-1 differentially directs linage specification of adipose- and bone marrow-derived mesenchymal stem cells. FASEB J 2019; 33:996-1007.
  • Wang JF, Lee MS, Tsai TL, Leiferman EM, Trask DJ, Squire MW, Li WJ. Bone morphogenetic protein-6 Attenuates type 1 diabetes mellitus-associated bone loss. Stem Cells Transl Med 2019; 8(6):522-534.
  • Li WJ, Jiao H, Walczak BE. Emerging opportunities for induced pluripotent stem cells in orthopedics. J Orthop Transl 2019; 17:73-81.


  • Jiang YC, Jiao HL, Lee MS, Wang T, Turng LS, Li Q, Li WJ. Endogenous biological factors modulated by substrate stiffness regulate endothelial differentiation of mesenchymal stem cells. J Biomed Mater Res A 2018; 106:1595-1603.


  • Lee PT, Li WJ. Chondrogenesis of embryonic stem cell-derived mesenchymal stem cells induced by TGFB1 and BMP7 through increased TGFB receptor expression and endogenous TGFB1 production. J Cell Biochem 2016; 118:172-181.
  • Tsai TL, Li WJ. Identification of bone marrow-derived soluble factors regulating human mesenchymal stem cells for bone regeneration. Stem Cell Reports 2017; 8:387-400.
  • Zhou Y, Tsai TL, Li WJ. Strategies to retain properties of bone marrow-derived mesenchymal stem cells ex vivo. Ann N Y Acad Sci 2017; 1409:3-17.
  • Ishihara S, Inman DR, Li WJ, Ponik SM, Keely RJ. Mechano-signal transduction of mesenchymal stem cells induces mammary cancer cell proliferation, but inhibits metastasis, via prosaposin secretion. Cancer Res 2017; 77:6179-6189.


  • Zhou Y, Zimber M, Yuan H, Naughton GK, Fernan R, Li WJ. Effects of human fibroblast-derived extracellular matrix on mesenchymal stem cells. Stem Cell Rev 2016; 12:560-572.
  • Yuan H, Zhou Y, Lee MS, Zhang Y, Li WJ. A newly identified mechanism involved in regulation of human mesenchymal stem cells by fibrous substrate stiffness. Acta Biomater 2016; 42:247-257.
  • Jin E, Lee PT, Jeon WB, Li WJ. Effects of elastin-like peptide on regulation of human mesenchymal stem cell behavior. Regen Eng Transl Med 2016; 2:85-97.
  • Chaudhary R, Lee MS, Mubyana K, Duenwald-Kuehl S, Kaiser J, Vanderby R, Eliceiri KW, Corr DT, Li WJ, Campagnola PJ, Halanski MA. The role of periosteal fibers in accelerated bone growth. Bone 2016; 92:201-213.


  • Handorf AM, Chamberlain CS, Li WJ. Endogenously-produced Indian hedgehog regulates TGFB-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev 2015; 24:995-1007.
  • Handorf AM, Zhou Y, Halanski MA, Li WJ. Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis 2015; 11:1-15.
  • Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther 2015; 6:88.
  • Jing X, Jin E, Mi HY, Li WJ, Peng XF, Turng LS. Hierarchically decorated electrospun poly(?-caprolactone)/nanohydroxyapatite composite nanofibers for bone tissue engineering. J Mater Sci 2015; 50:4174-4186.
  • Chiu CY, Tsai TL, Vanderby R, Bradica G, Lou SL, Li WJ. Osteoblastogenesis of mesenchymal stem cells in 3-D culture enhanced by low-intensity pulsed ultrasound through soluble receptor activator of nuclear factor kappa B ligand. Ultrasound Med Bio 2015; 41:1842-1852.


  • Saether EE, Chamberlain CS, Leiferman EM, Kondratko-Mittnacht JR, Li WJ, Brickson SL, Vanderby R. Enhanced medial collateral ligament healing using mesenchymal stem cells: dosage effects on cellular response and cytokine profile. Stem Cell Rev 2014; 10:86-96.
  • Handorf AM, Li WJ. Induction of mesenchymal stem cell chondrogenesis through sequential administration of growth factors within specific temporal windows. J Cell Physio 2014; 229:162-171.
  • Palumbo S, Tsai TL, Li WJ. Macrophage migration inhibitory factor regulate Akt signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells. Stem Cells Dev 2014; 23:852-865.
  • Tsai TL, Nelson BC, Anderson PA, Zdeblick TA, Li WJ. Intervertebral disc and tem cells co-cultured in biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor. Spine J 2014; 14:2127-2140.
  • Czaplewski SK, Tsai TL, Duenwald-Kuehl SE, Vanderby R Jr, Li WJ. Tenogenic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells dictated by properties of braided nanofibrous scaffolds. Biomaterials 2014; 35:6907-6917.
  • Brown PT, Squire MW, Li WJ. Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Cell Tissue Res 2014; 358:149-164.
  • Mi HY, Palumbo S, Jing X, Turng LS, Li WJ, Peng XF. Thermoplastic polyurethane/hydroxyapatite electrospun scaffolds for bone tissue engineering: effect of polymer properties and particle size. J Biomed Mater Res Part B 2014; 102:1434-1444.


  • Tsai TL, Manner PA, Li WJ. Regulation of mesenchymal stem cell chondrogenesis by glucose through protein kinase C/Transforming growth factor signaling. Osteoarthritis Cartilage 2013; 21:368-376.
  • Barber JG, Handorf AM, Allee TJ, Li WJ. Braided nanofibrous scaffold for tendon and ligament tissue engineering. Tissue Eng Part A 2013; 19:1265-1274.
  • Brown PT, Handorf AM, Jeon WB, Li WJ. Stem cell-based tissue engineering approaches for musculoskeletal regeneration. Curr Pharm Des 2013; 19: 3429-3445.
  • Palumbo SL, Li WJ. Osteoprotegerin enhances osteogenesis of human mesenchymal stem cells. Tissue Eng Part A 2013; 319:1942-1955.
  • Pflum ZE, Palumbo SL, Li WJ. Adverse effect of demineralized bone powder on osteogenesis of human mesenchymal stem cells. Exp Cell Res 2013; 319:1942-1955.


  • Cui ZX, Nelson B, Peng YY, Li K, Pilla S, Li WJ, Turng LS, Shen CY. Fabrication and characterization of injection molded poly(epsilon-caprolactone) and poly(epsilon-caprolactone)/hydroxyaptite scaffolds for tissue engineering. Mater Sci Eng C Mater Biol Appl 2012; 32:1674-1681.
  • Koepsel JT, Brown PT, Loveland SG, Li WJ, Murphy WL. Combinatorial screening of chemically defined human mesenchymal stem cell culture substrates. J Mater Chem 2012; 22:19474-19481.


  • Handrof AM, Li WJ. Fibroblast growth factor-2 primes human mesenchymal stem cells for enhanced chondrogenesis. PLoS One 2011; 6:e22887.
  • Giri J, Li WJ, Tuan RS, Cicerone MD. Stabilization of proteins by nanoencapsulation in sugar-glass for tissue engineering and drug delivery applications. Adv Mater 2011; 23:4861-4867.


  • Barber JG, Li WJ. Nanostructured scaffolds for biology and tissue engineering. Nano Life 2010; 1&2:109-120.


  • Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng Part B Rev 2009; 15:171-193.
  • Baker BM, Handorf AM, Ionescu LC, Li WJ, Mauck RL. New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev Med Devices 2009; 6:515-532.