Our lab is dedicated to exploring the potential of stem cells for cartilage and bone regeneration, engaging in both fundamental and translational research on the biology and applications of stem cells, including mesenchymal stem/stromal cells and induced pluripotent stem cells derived from human tissues. Over the past decade, our research has identified several key molecules and mechanisms that govern the cartilage- and bone-specific differentiation of stem cells and has developed effective approaches for tissue regeneration.
Derivation of Hyaline Chondrocytes from Stem Cells
Regenerating hyaline cartilage from stem cells remains a significant challenge. To address this, our team employs a strategy of controlled induction of chondrogenesis in stem cells, following developmental pathways. We focus on identifying and manipulating molecular regulators to guide stem cells into becoming hyaline chondrocytes in a controlled environment.
Rejuvenation of Mesenchymal Stem/Stromal Cells
Aging and cellular senescence reduce the growth and differentiation capabilities of stem cells. Cellular reprogramming, a laboratory technique, has shown potential in mitigating cellular senescence. Our research investigates the cellular and molecular changes in stem cells in response to cellular reprogramming, aiming to develop methods to rejuvenate aging stem cells.
Osteoarthritis Modeling and Drug Screening
Using induced pluripotent stem cells from patients with osteoarthritis allows us to recapitulate the disease process in culture, providing a human cell-based model that is otherwise challenging to obtain. This iPSC-based chondrogenic model is utilized to identify key disease-associated molecules and therapeutic targets, which are critical for developing potential treatments.