Current Support
1) Title: Braided Nanofibers and Embryonic Stem Cells for Ligament Tissue Engineering
Source: 3M (Nontenured Faculty Award) (233-PRJ71FE)
Role: Principal Investigator
Dates: 03/01/2013-02/28/2016
Amount: $45,000
Description: The goal of this study is to tissue engineer functional ligaments using braided nanofibers and embryonic stem cells.
2) Title: hECM for Intervertebral Disc Tissue Engineering
Source: PUR Biologics (MSN187773)
Role: Principal Investigator
Dates: 07/01/2015-12/31/2015
Amount: $15,000
Description: This study aims to tissue engineer an intervertebral disc (IVD) using human mesenchymal stem cells (hMSCs) and annulus fibrosus cells (AFCs) or nucleus pulposus cells (NPCs) cocultured in a hECM-based composite scaffold.
3) Title: Biomaterials for Local Regulation of Growth Factor Signaling
Source: NIH/NHLBI
Role: Co-Investigator (PI: William Murphy)
Dates: 07/01/2015-06/30/2019
Amount: $1,870,100
Description: This proposed research program will develop a new class of materials that can be used to control the effects of growth factors during stem cell culture and engineered tissue development, particularly vascular tissue development.
4) Title: Blood-derived Induced Pluripotent Stem Cells for Cartilage Repair
Source: NIH/NIAMS
Role: Principal Investigator (Co-I: Igor Slukvin, Mark Markel, Marcus Cicerone)
Dates: 08/01/2015-07/31/2020
Amount: $1,891,300
Description: The objective of this proposal is to develop an effective tissue engineering therapy for treatment of osteoarthritis by exploring the potential of using iPSC-derived MSCs to generate engineered cartilage in vitro as an implant for cartilage repair in vivo.
Past Support
1) Title: A Novel Biomimetic Allograft Bone Powder-Nanofibrous Scaffold Bone Substitute
Source: Musculoskeletal Transplant Foundation
Role: Investigator (PI: Leon Nesti)
Dates: 01/01/2006-12/31/2006
Amount: $120,000
Description: This goal of this study is to tissue engineer bone in vitro using human mesenchymal stem cells, biodegradable nanofibers, and human bone powders.
2) Title: Intervertebral Disc Regeneration from Co-cultured Disc and Stem Cells in Biomimetic Engineered Extracellular Matrix Stimulated by Mechanically Active Bioreactor
Source: North American Spine Society (Young Investigator Award) (133-PRJ19VR)
Role: Principal Investigator
Dates: 09/01/2008-08/31/2011
Amount: $49,000
Description: The goal of this study is to tissue engineer intervertebral disc using a biomimetic nanofiber/hyaluronic acid gel composite structure.
3) Title: Biphasic Nanofiber/bone Powder Implants Grown in a Compressive Bioreactor for Osteochondral Repair
Source: AO Foundation (S-09-43L)
Role: Principal Investigator (Co-I: Mark Markel)
Dates: 09/01/2009-08/31/2012
Amount: $120,000
Description: The goal of this study is to tissue engineer biphasic osteochondral implants based on mesenchymal stem cell-laden nanofibrous scaffolds cultured in a compressive loading-active bioreactor.
4) Title: Cell-based Tissue Regeneration using Elastin-mimetic Extracellular Matrix Protein
Source: The Ministry of Education, Science and Technology of the Republic of Korea (10-BD-02)
Role: Principal Investigator (Co-PI: Won Bae Jeon)
Dates: 09/01/2011-12/31/2012
Amount: $260,000
Description: This study investigates the potential of elastin-mimetic extracellular matrix (EMECM) protein as a novel biomaterial for stem cell-based musculoskeletal regeneration.
5) Title: Induced Pluripotent Stem Cells Differentiated in Engineered Matrix with a Bio-inspired Surface for Tendon Regeneration
Source: UW Institute for Clinical and Translational Research and UW Stem Cell & Regenerative Medicine Center (233-PRJ51ZA)
Role: Principal Investigator (Co-I: Igor Slukvin, William Murphy, and Ray Vanderby)
Dates: 09/01/2011-08/31/2013
Amount: $50,000
Description: This study investigates tendon regeneration from stem cells induced and cultured in braided nanofibrous scaffolds (BNFSs).
6) Title: High-throughput Perfusion Culture System
Source: UW-Madison Graduate School (101-PRJ61XE)
Role: Principal Investigator (Co-I: Thomas Yen and Steven Goodman)
Dates: 07/01/2012-06/30/2013
Amount: $50,000
Description: This study is to develop and fabricate a high-throughput culture system with a perfusion capacity to enhance growth and differentiation of stem cell pellets.
7) Title: TGFB1 and BMP7 Regulation of Chondrogenesis in Mesenchymal Stem Cells Derived from Embryonic Stem Cells
Source: UW-School of Medicine and Public Health (233-PRJ73KV)
Role: Principal Investigator
Dates: 07/01/2013-06/30/2014
Amount: $30,000
Description: This study aims to elucidate the mechanism underlying chondrogenesis of ESC-derived MSCs induced by TGFB1 and BMP7.
8) Title: Induced Pluripotent Stem Cells Differentiated in Engineered Matrix with a Bio-inspired Surface for Tendon Regeneration – in vivo study
Source: UW Institute for Clinical and Translational Research and UW Stem Cell & Regenerative Medicine Center (233-PRJ75AR)
Role: Principal Investigator (Co-I: Igor Slukvin, William Murphy, and Ray Vanderby)
Dates: 08/01/2013-07/31/2014
Amount: $30,000
Description: This study investigates repair of tendon defects by tissue-engineered tendon derived from human iPSCs in rabbits.
9) Title: Blood-derived Induced Pluripotent Stem Cells for Cartilage Repair
Source: Wisconsin Alumni Research Foundation (135-PRJ85UL)
Role: Principal Investigator
Dates: 06/26/2014-06/30/2015
Amount: $45,000
Description: The objective of this proposal is to develop an effective tissue engineering therapy for treatment of osteoarthritis by exploring the potential of using iPSC-derived MSCs to generate engineered cartilage in vitro.